Skyscape Inc.

06/09/2026

🩺 𝗧𝗢𝗗𝗔𝗬'𝗦 𝗠𝗘𝗗𝗕𝗘𝗔𝗧𝗦 — 𝗠𝗶𝗿𝘁𝗮𝘇𝗮𝗽𝗶𝗻𝗲 𝗺𝗮𝘆 𝗼𝗳𝗳𝗲𝗿 𝗻𝗲𝘄 𝗵𝗼𝗽𝗲 𝗳𝗼𝗿 𝗺𝗲𝘁𝗵𝗮𝗺𝗽𝗵𝗲𝘁𝗮𝗺𝗶𝗻𝗲 𝘂𝘀𝗲 𝗱𝗶𝘀𝗼𝗿𝗱𝗲𝗿.
A recent randomized clinical trial found that mirtazapine (30 mg/day) significantly reduced methamphetamine use compared with placebo in adults receiving routine clinical care. Researchers also reported no unexpected safety concerns during the 12-week study period.
While the treatment effect was modest, the findings are important because there are currently no FDA-approved medications for methamphetamine use disorder.

𝗞𝗲𝘆 𝗳𝗶𝗻𝗱𝗶𝗻𝗴𝘀:
🔹 Reduced methamphetamine use days versus placebo
🔹 Conducted in real-world outpatient settings
🔹 No major unexpected safety issues identified
🔹 Potential new pharmacologic option for a difficult-to-treat condition

𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲 𝗼𝗻 𝗠𝗲𝗱𝗕𝗲𝗮𝘁𝘀:
https://medbeats.skyscape.com/psychiatry/13751/2026.06.09.01/mirtazapine-for-methamphetamine-use-disorder

𝗙𝗼𝗿 𝗮𝗹𝗹 𝘁𝗵𝗲 𝘁𝗶𝘁𝗹𝗲𝘀 📱𝗦𝗸𝘆𝘀𝗰𝗮𝗽𝗲 𝗠𝗼𝗯𝗶𝗹𝗲 𝗔𝗽𝗽𝘀 𝗳𝗼𝗿 𝗣𝘀𝘆𝗰𝗵𝗶𝗮𝘁𝗿𝘆: 💬 See the first comment below for your download link 👇

In this phase 3 randomized clinical trial, mirtazapine produced a modest but statistically significant reduction in methamphetamine use among individuals with moderate to severe methamphetamine use disorder. The medication demonstrated an acceptable safety profile, with drowsiness and weight gain be...

06/08/2026

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06/08/2026

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𝗟𝗶𝗻𝗸𝘀 𝗮𝗿𝗲 𝗶𝗻 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝗰𝗼𝗺𝗺𝗲𝗻𝘁 𝗯𝗲𝗹𝗼𝘄 👇

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06/08/2026

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06/08/2026

🩺 𝗧𝗢𝗗𝗔𝗬'𝗦 𝗠𝗘𝗗𝗕𝗘𝗔𝗧𝗦 — 𝗦𝗚𝗟𝗧𝟮 𝗜𝗻𝗵𝗶𝗯𝗶𝘁𝗼𝗿𝘀 𝗦𝗵𝗼𝘄 𝗣𝗿𝗼𝗺𝗶𝘀𝗶𝗻𝗴 𝗢𝘂𝘁𝗰𝗼𝗺𝗲𝘀 𝗶𝗻 𝗣𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝘄𝗶𝘁𝗵 𝗣𝘀𝗼𝗿𝗶𝗮𝘀𝗶𝘀 𝗮𝗻𝗱 𝗧𝘆𝗽𝗲 𝟮 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀

A recent population-based target trial emulation evaluated the 𝗲𝗳𝗳𝗶𝗰𝗮𝗰𝘆 𝗮𝗻𝗱 𝘀𝗮𝗳𝗲𝘁𝘆 of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with psoriasis and comorbid type 2 diabetes mellitus.

The study demonstrated that SGLT2i therapy was associated with:

✅ 𝗟𝗼𝘄𝗲𝗿 𝗮𝗹𝗹-𝗰𝗮𝘂𝘀𝗲 𝗺𝗼𝗿𝘁𝗮𝗹𝗶𝘁𝘆
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✅ Reduced risks of 𝗮𝘀𝘁𝗵𝗺𝗮, 𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻, 𝘀𝗹𝗲𝗲𝗽 𝗱𝗶𝘀𝗼𝗿𝗱𝗲𝗿𝘀, and 𝗺𝗮𝗹𝗶𝗴𝗻𝗮𝗻𝗰𝗶𝗲𝘀 compared with GLP1 receptor agonists

These findings support the potential role of SGLT2 inhibitors as an adjunct therapeutic strategy in patients with psoriasis and type 2 diabetes.

📖 Read more on MedBeats:

https://medbeats.skyscape.com/dermatology/13750/2026.06.08.01/safety-and-effectiveness-of-sodium-gl…

📱 𝐄𝐱𝐩𝐥𝐨𝐫𝐞 𝐨𝐮𝐫 𝐟𝐮𝐥𝐥 𝐜𝐨𝐥𝐥𝐞𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐃𝐞𝐫𝐦𝐚𝐭𝐨𝐥𝐨𝐠𝐲 𝐚𝐩𝐩𝐬 𝐟𝐫𝐨𝐦 𝐒𝐤𝐲𝐬𝐜𝐚𝐩𝐞 — 𝐥𝐢𝐧𝐤𝐬 𝐚𝐫𝐞 𝐢𝐧 𝐭𝐡𝐞 𝐟𝐢𝐫𝐬𝐭 𝐜𝐨𝐦𝐦𝐞𝐧𝐭 👇

06/06/2026

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06/05/2026

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06/05/2026

🩺 𝗧𝗢𝗗𝗔𝗬'𝗦 𝗠𝗘𝗗𝗕𝗘𝗔𝗧𝗦 — 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗼𝗺𝗶𝗰𝘀 𝗼𝗳 𝗥𝗶𝗴𝗵𝘁 𝗩𝗲𝗻𝘁𝗿𝗶𝗰𝘂𝗹𝗮𝗿 𝗙𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗶𝗻 𝗣𝘂𝗹𝗺𝗼𝗻𝗮𝗿𝘆 𝗛𝘆𝗽𝗲𝗿𝘁𝗲𝗻𝘀𝗶𝗼𝗻

A recent multicenter 𝗣𝗩𝗗𝗢𝗠𝗜𝗖𝗦 cohort study explored how circulating metabolites are linked to right ventricular systolic function across the spectrum of pulmonary hypertension.

📌 𝗞𝗲𝘆 𝗳𝗶𝗻𝗱𝗶𝗻𝗴𝘀:
🔹 𝟭𝟳𝟬 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲𝘀 were significantly associated with RV systolic function
🔹 Androgenic steroid, vitamin A, fatty acid, sterol, and glutathione-related pathways showed strong associations
🔹 Certain 𝗮𝗻𝗱𝗿𝗼𝗴𝗲𝗻𝗶𝗰 𝘀𝘁𝗲𝗿𝗼𝗶𝗱𝘀 demonstrated stronger associations in females
🔹 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲-𝗯𝗮𝘀𝗲𝗱 𝘀𝗰𝗼𝗿𝗲𝘀 showed prognostic value comparable to RV function metrics

These findings may help advance precision phenotyping and future biomarker-driven strategies in the management of pulmonary hypertension.

📖 𝗥𝗲𝗮𝗱 𝗺𝗼𝗿𝗲:
https://medbeats.skyscape.com/cardiology/13748/2026.06.04.01/metabolomics-of-right-ventricular-function-in-pulmonary-hypertension

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The findings suggest that steroid hormone pathways, vitamin A metabolism, glutathione-related pathways, fatty acid metabolism, and polyamine metabolism may play important roles in RV adaptation and dysfunction. The observation that androgenic steroid metabolites have stronger associations with RV fu...