09/10/2026
๐ ๐ฃ๐๐ฏ๐น๐ถ๐ฐ๐ฎ๐๐ถ๐ผ๐ป ๐๐ฝ๐ผ๐๐น๐ถ๐ด๐ต๐: ๐๐ฐ๐๐๐ฒ ๐ฝ๐ต๐๐๐ถ๐ผ๐น๐ผ๐ด๐ถ๐ฐ๐ฎ๐น ๐ฒ๐ณ๐ณ๐ฒ๐ฐ๐๐ ๐ผ๐ณ ๐๐ฎ๐ฐ๐ถ๐น๐น๐๐ ๐๐๐ฏ๐๐ถ๐น๐ถ๐ ๐๐๐ญ๐ญ๐ญ (๐ฎ๐ฌ๐ฎ๐ฎ)
Looking back at this randomized, double-blinded, placebo-controlled human study published in Beneficial Microbes - scientific journal, the researchers set out to explore what happens in the human small intestine just hours after probiotic ingestion - a biological window that is rarely accessible.
Using ileostomy samples collected four hours after oral intake of Bacillus subtilis DE111, the study combined metabolomics, proteomics, and metagenomics to capture early molecular responses. The results revealed rapid changes in metabolic profiles, immune-related protein expression, and lipid-associated pathways, while microbiome composition remained largely stable aside from the presence of the probiotic itself.
Biogenity provided proteomics data acquisition, processing, and analysis, supporting protein-level insights into immune regulation and lipid metabolism observed shortly after ingestion. ๏ฟผ
Looking back, studies like this highlight how integrated omics approaches can reveal immediate physiological effects that would otherwise remain hidden.
๐ ๐ฅ๐ฒ๐ฎ๐ฑ ๐๐ต๐ฒ ๐ฎ๐ฟ๐๐ถ๐ฐ๐น๐ฒ: https://doi.org/10.3920/BM2022.0081
