05/13/2026
Post hoc analysis from the European Journal of Preventive Cardiology explored whether achieved LDL-C levels after CABG are linked to saphenous vein graft (SVG) patency.
In the NEWTON-CABG CardioLink-5 trial, patients receiving evolocumab evolocumab or placebo showed no difference in overall graft outcomes. However, when looking at achieved LDL-C at 3 months, a clear pattern emerged: lower LDL-C was associated with less SVG occlusion at 2 years, independent of treatment assignment.
Each 1 mmol/L reduction in LDL-C was associated with improved graft patency (OR 0.74, P=0.005).
While post hoc, these findings reinforce a consistent message in post-CABG careβlower achieved LDL-C may translate into better graft outcomes and supports guideline-driven lipid lowering in high-risk patients!
Read the full study in the European Journal of Preventive Cardiology.
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