16/10/2026
A cancer treatment invented at the University of Michigan is being hailed as one of the most significant non-invasive breakthroughs in oncology in decades.
Histotripsy uses focused ultrasound waves to mechanically destroy tumor tissue without a single incision, drug, or beam of radiation. Invented in 2002 by biomedical engineering professor Zhen Xu and her team, the method fires microsecond-long sound pulses that generate microscopic bubbles inside the tumor.
These bubbles rapidly expand and collapse, obliterating the cancer cells from the inside out through pure mechanical force.
In October 2023, the FDA approved histotripsy for liver tumors, commercialized through the U-M spinoff HistoSonics. Thousands of patients have already been treated, and clinical trials are now aggressively targeting kidney and prostate cancers.
Crucially, researchers discovered that even destroying part of a tumor triggers the body's immune system to fight off the rest.
To weaponize this technology globally, the university recently launched a $10 million Histotripsy Center.
The facility aims to expand the treatment to thyroid, pancreas, breast, brain, skin, and sarcoma cancers, while opening its equipment to global researchers for free.
Leaders believe this revolution will secure widespread approvals, transforming care for hundreds of thousands of patients within five years.