06/06/2023
1/8 🧬 In the quest for longevity, NAD and its precursors NMN & NR have emerged as potential contenders. NAD is a critical molecule involved in 500+ metabolic reactions in our body, but its levels decrease with age. Could supplementing with NAD help reverse aging?
2/8 💊 However, NAD is poorly absorbed, making oral supplementation impractical. Scientists have turned to NAD precursors, NMN & NR, which show greater bioavailability. But the evidence supporting their benefits is still largely theoretical.
3/8 📚 A recent study on 80 healthy adults aged 40-65 given varying doses of NMN for 60 days found that NMN supplementation led to significant increases in blood NAD concentrations and was safe and well-tolerated.
4/8 📈 The study also suggested a potential age-preserving effect of NMN supplementation and improved endurance. But the study's methodology and choice of metrics have been criticized.
5/8 📉 The Aging.Ai 3.0 calculator used to gauge blood biological age has been questioned for its accuracy and reliability. And the six-minute walking test (6MWT) used to measure endurance may not be a valid measure of fitness in healthy adults.
6/8 🏃♀️ The study also did not take into account other factors such as heart rate, perceived exertion, and recovery time, which could provide a more holistic understanding of physical performance.
7/8 📊 The study's results were statistically significant, but they may not have clinical significance. This means they may not be practically important or meaningful in a real-world context.
8/8 🧪 In conclusion, while the study shows that NMN supplementation raises circulating NAD, the results on aging and clinically relevant physical performance do not provide solid evidence of the health or longevity benefits of NMN. More rigorous studies are needed.
